Evaluation of the <em>in vitro</em> anti-inflammatory activity of different fractions of the aqueous extract of <em>Curcuma zedoaria</em> Roscoe rhizome and formulation of a cream with anti-inflammatory potential

Introduction: Curcuma zedoaria Roscoe (C. zedoaria) is used in traditional medicine for various diseases, including inflammation. This study aimed to evaluate the vitro anti-inflammatory activity of aqueous extract C. rhizome and its fractions develop an cream incorporating extract. Methods: The crude was prepared by decoction method. A portion it freeze-dried other part subjected sequential fractionation using hexane, dichloromethane ethyl acetate. All were dried a rotary vacuum evaporator. dry powders above extracts assessed their heat-induced egg albumin denaturation assay compared with reference drug, diclofenac sodium. formulated most effective fraction; against commercially available sodium cream. Results: dichloromethane, acetate remaining showed protein IC50 values; 94.45 µg/mL, 3822 373.2 337.7 µg/mL 565.4 respectively. value obtained powder 915.7µg/mL. (containing 3% w/w rhizome) 1894 µg/mL. observed 1% 1227 Conclusion: possesses efficacy. Further studies are required improve drug-releasing capacity.